Anticonvulsant activity and toxicity evaluation of Cu(II) and Zn(II) metal complexes derived from triazole-quinoline ligands.

نویسندگان

  • Naveen Vasudev Kulkarni
  • Srinivasa Budagumpi
  • Gurunath Suresh Kurdekar
  • Vidyanand Krishna Revankar
  • Suresh Didagi
چکیده

A novel Cu(II) and Zn(II) complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock induced seizures in Wistar rats and possesses low toxicity, providing a high safety profile.

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عنوان ژورنال:
  • Chemical & pharmaceutical bulletin

دوره 58 12  شماره 

صفحات  -

تاریخ انتشار 2010